Oral Presentation HUPO 2019 - 18th Human Proteome Organization World Congress

    The Human Protein Atlas - Implications for Human Biology, Drug Development and Precision Medicine (#41)

Mathias Uhlen 1
  1. KTH Royal Institute of Technology, Stockholm, NA, Sweden

The Human Protein Atlas (HPA) is an international program with the aim to map of all the human proteins in cells, tissues and organs using integration of various omics technologies, including genomics, transcriptomics, antibody-based imaging, mass spectrometry-based proteomics and systems biology. The current version (www.proteinatlas.org) consists of three separate parts, each focusing on a particular aspect of the genome-wide analysis of the human proteins; (1) the Tissue Atlas showing the distribution of the proteins across all major tissues and organs in the human body, (2) the Cell Atlas showing the subcellular localization of proteins in single cells, and (3) Pathology Atlas showing the impact of protein levels for survival of patients with cancer. This year we plan to also launch a new Brain and a new Blood Atlas. All the data in the knowledge resource is open access to allow scientists both in academia and industry to freely access the data for exploration of the human proteome. We have used this resource to launch various efforts in the field of Precision Medicine. We have also launched a Human Secretome Project to produce in mammalian cell cultures all human secreted proteins (4). The progress of this project will be discussed and the results from phenotypic screening of this resource will be presented.

  1. Uhlen et al (2015) Science 347: 1260419
  2. Thul et al (2017) Science356 (6340): eaal3321
  3. Uhlen et al (2017) Science357 (6352): eaan2507
  4. Uhlen et al (2018) BioRxiv, https://doi.org/10.1101/465815