Poster Presentation HUPO 2019 - 18th Human Proteome Organization World Congress

High-throughput mass-spectrometry-based analysis of endogenous peptide-HLA I thermal stability improves the prediction of T cell epitopes (#595)

Emma C Jappe 1 2 , Nathan P Croft 3 , Christian Garde 1 , Ethan Passantino 3 , Thomas Trolle 1 , Jens V Kringelum 1 , Anthony W Purcell 3
  1. Evaxion Biotech, Copenhagen, COPENHAGEN, Denmark
  2. Department of Health Technology, Technical University of Denmark, 2800 Lyngby, Denmark
  3. Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800
Publish consent withheld
  1. Yewdell, J. W., Reits, E. & Neefjes, J. Making sense of mass destruction: Quantitating MHC class I antigen presentation. Nat. Rev. Immunol. 3, 952–961 (2003).
  2. Gfeller, D., Bassani-Sternberg, M., Schmidt, J. & Luescher, I. F. Current tools for predicting cancer-specific T cell immunity. Oncoimmunology 5, 1–9 (2016).
  3. Koşaloğlu-Yalçın, Z. et al. Predicting T cell recognition of MHC class I restricted neoepitopes. Oncoimmunology 7, 1–15 (2018).
  4. Rasmussen, M. et al. Pan-Specific Prediction of Peptide–MHC Class I Complex Stability, a Correlate of T Cell Immunogenicity. J. Immunol. 197, 1517–1524 (2016).
  5. Blaha, D. T. et al. High-Throughput Stability Screening of Neoantigen / HLA Complexes Improves Immunogenicity Predictions. 7, 50–62 (2019).