Acute myeloid leukemia (AML) is a frequent hematological malignancy. Despite enormous therapeutic efforts that range from various cytotoxic agents to allogeneic stem cell transplantation, overall survival of patients with AML remains unsatisfying. The poor survival rates are mainly due to therapy-related mortality, failure of induction chemotherapy and early relapse. In this study, we investigated the possible role of protein post translational modifications on 3 AML subtypes; KMT2A t(9-11), normal karyotype and complex karyotype in an attempt to better understand the mechanistic and cancer pathophysiology. Our finding revealed that a characteristic pattern in acetylation and ubiquitination of c terminal zing finger protein might be a good prognostic indicator.