Poster Presentation HUPO 2019 - 18th Human Proteome Organization World Congress

Comparative Proteome Profiling of Acute Myelogenous Leukemia Cell Lines under acute and chronic starvation condition (#762)

Aya Osama 1 , Eman Ahmed 1 , shahd ezzeldin 1 , Sameh Magdeldin 1
  1. Children Cancer Hospital 57357, Cairo, CAIRO, Egypt

Myeloid leukemias are a heterogeneous group of diseases originating from bone marrow myeloid progenitor cells.  Patients with myeloid leukemias can achieve long-term survival through targeted therapy, cure after intensive chemotherapy or short-term survival because of highly chemoresistant disease. To elucidate the proteomic characteristics AML, we applied a comparative analysis between different leukemic cell lines under acute and chronic starvation conditions. Here we tested acute promyelocytic leukemia (HL60), acute myeloid leukemia (Kasumi), acute myeloid leukemia (Nomo-I) and acute myelomonocytic leukemia (ML-2). Our finding revealed significant and characteristic metabolic cell dependent pathways reflecting different resistance capabilities between AML cell lines. This finding might be helpful to better understand chemoresistance patterns between different AMLs and associated recovery of patients.