Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease in Asia area from 2013. The major clinical symptoms of SFTS are fever, vomiting, diarrhea, multiple organ failure, thrombocytopenia , leucopenia and elevated liver enzyme levels, showing its fatality rates ranging from 12% to as high as 30%. SFTS virus is a phlebovirus in the family of Bunyaviridae, and consist of 3 gene segments, large (L), medium (M) and small (S). And 6 proteins have been identified—an RNA dependent RNA polymerase (RdRp), a glycoprotein precursor (M), a glycoprotein N (Gn), a glycoprotein C (Gc), a nuclear protein (NP) and a non structural protein (NSs). In this study, using immunoproteomics approach coupled with high resolution LC-MS platform, several highly immunogenic SFTSv antigens were discovered. Those antigens are expected to be applied in vaccine development and rapid detection kit development. Also, immunoproteomic approach shows its possibility as a useful tool for antigen discovery.