Programmatic access to open database resources are as important as it can be a tough exercise to get right. In the latest version of the Human Protein Atlas portal (www.proteinatlas.org, v19) we have addressed this by adding new ways to export the data following the FAIR principles as well as providing more comprehensive datasets, both for the new Blood and Brain atlases, but also for external sources. In terms of functionality, we have extended the XML format, added custom data selection and JSON format export for user generated searches as well as added access to remapped transcriptome data from external sources. These new features will empower researchers in using the Human Protein Atlas in more advanced ways.