Oral Presentation HUPO 2019 - 18th Human Proteome Organization World Congress

The International Cancer Proteogenome Consortium (ICPC): innovation and collaboration inspired by the Cancer MoonshotSM (#170)

Ana I Robles 1 , Henry Rodriguez 1
  1. National Cancer Institute, Bethesda, MD, United States

The successes of the Clinical Proteomic Tumor Analysis Consortium (CPTAC) led NCI to strengthen its commitment to proteogenomic research. The International Cancer Proteogenome Consortium (ICPC), inspired by the spirit of international collaboration and data sharing encouraged by the Cancer Moonshot, started in 2016 and its vision is aligned with the Moonshot goals of accelerating progress in cancer research and its translation to patient care. ICPC encourages international cooperation and investments in proteogenomic cancer research. Aligned with CPTAC, ICPC brings together some of the world’s leading cancer and proteogenomic research centers that adopt standard operating procedures for biospecimen collection and harmonized proteogenomic technologies/workflows to characterize commonly diagnosed cancers in their respective populations and address their specific unmet clinical needs. Its mission is to develop a cancer proteogenome atlas representative of the diversity of people with cancer worldwide, while implementing strategies to compare proteomic datasets generated using different platforms. The ICPC currently includes 33 institutions from 13 countries. Each institution has committed to publicly releasing study data (genomics, clinical phenotype, proteomics raw files, proteomic assays, antibodies, medical imaging) to the global research community. Currently, 13 cancer types are under characterization at the various sites. ICPC teams have local scientific and/or outreach activities, including roundtables and training workshops. A study using common internal standard reference materials will be conducted to harmonize workflows from sample preparation to informatics analysis across sites. Three ICPC data sets, comprising gastric cancer, liver cancer, and oral squamous cell carcinoma, are already hosted at the CPTAC Data Portal, a centralized repository for the public dissemination of CPTAC proteomic datasets. In the future, harmonized proteomic data from NCI-supported projects, including CPTAC, ICPC and others, such as Applied Proteogenomics OrganizationaL Learning and Outcomes (APOLLO), will be hosted at the NCI’s Proteomic Data Commons (PDC), a cloud-based resource currently launched in Beta-phase.