Oral Presentation HUPO 2019 - 18th Human Proteome Organization World Congress

Onco-proteogenomics: toward a more complete understanding of cancer biology (#195)

Bing Zhang 1
  1. BAYLOR COLLEGE OF MEDICINE, Houston, TX, United States

Cancer is a disease of the genome, but many processes downstream of the genome can affect the tumor phenotype. Using proteogenomics data from the Clinical Proteomic Tumor Analysis Consortium (CPTAC), I will present examples on how proeogenomic integration can expand our knowledge on cancer genes, prioritize cancer drivers, clarify puzzling genomic observations, and correct misinterpreted gene functions. I will also discuss our recent works on using proteogenomics to identify tumor antigens and understand immune evasion mechanisms.