Recent technological advances as well as longitudinal monitoring not only have the potential to improve the treatment of disease (Precision Medicine) but also empower people to stay healthy (Precision Health). We have performed to studies to examine human health and diversity. First, we have profile 109 participants using multiomics technologies (genomics, immunomics, transcriptomics, proteomics, metabolomics, microbiomics and wearables etc) for up to eight years and made 49 major health discoveries. Second, to understand human diversity from around the world, we have begun to profile more than 300 people who attended the HUPO meetings over the past three years using multiomics technologies. The results of these studies will be presented.