Poster Presentation HUPO 2019 - 18th Human Proteome Organization World Congress

Progress on identifying and characterizing the human proteome: 2018-2019 metrics from the HUPO Human Proteome Project (#758)

Gil Omenn 1 , Lydie Lane 2 , Chris Overall 3 , Fernando J Corrales 4 , Jochen M Schwenk 5 , Young-Ki Paik 6 , Jennifer E. Van Eyk 7 , Siqi Liu 8 , Stephen Pennington 9 , Michael P Snyder 10 , Mark S. Baker 11 , Eric W Deutsch 12
  1. University of Michigan,, Ann Arbor, MI, United States
  2. CALIPHO Group, SIB Swiss Institute of Bioinformatics and Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, CMU,, Geneva, Switzerland
  3. Life Sciences Institute, Faculty of Dentistry, University of British Columbia, Vancouver, BC, Canada
  4. Centro Nacional de Biotecnologia (CSIC), Madrid, Spain
  5. Science for Life Laboratory, KTH Royal Institute of Technology, Solna, Sweden
  6. Yonsei Proteome Research Center, Yonsei University, Seoul, South Korea
  7. Advanced Clinical BioSystems Research Institute, Cedars Sinai Precision Biomarker Laboratories, Barbra Streisand Women’s Heart Center, Cedars-Sinai Medical Center, Los Angeles, CA, United States
  8. BGI Group-Shenzhen, Shenzhen, China
  9. School of Medicine, University College Dublin, Conway Institute, Dublin, Ireland
  10. Department of Genetics, Stanford University, Palo Alto, CA, United States
  11. Department of Biomedical Sciences, Faculty of Medicine & Health Sciences, Macquarie University, Sydney, Macquarie Park NSW 2109, Australia
  12. Institute for Systems Biology, Seattle, WA, United States

The Human Proteome Project (HPP) annually reports on progress made throughout the field in credibly identifying and characterizing the complete human protein parts list and making proteomics an integral part of multi-omics studies in medicine and the life sciences.  NeXtProt release 2019-01-11 contains 17,694 PE1 proteins, which represent 89% of all 19,823 neXtProt predicted coding genes (all PE1, 2, 3, 4 proteins), up from 17,470 in release 2018-01.  Conversely, the number of neXtProt PE2, 3, 4 proteins, called the “missing proteins” (MPs), has been reduced from 2,949 to 2,129 over the past three years.  Since the inception of the Human Proteome Project, PeptideAtlas has been the source of uniformly re-analyzed raw mass spectrometry data for neXtProt.  PeptideAtlas gained 495 canonical proteins between 2018 and 2019.  Multiple strategies have been employed to detect hard-to-identify proteins.  Meanwhile, the Human Protein Atlas has released version 18.1 with immunohistochemical evidence of  expression of 17,000 proteins, survival plots as part of the Pathology Atlas, and its Cell Atlas, and is moving toward completion of a harmonized resource on tissue-specific RNA expression data.  Many investigators apply multiplexed SRM-targeted proteomics for quantitation of organ-specific popular proteins in studies of various human diseases.  The 19 teams of the Biology and Disease-driven B/D-HPP published a total of 382 publications in 2018, bringing proteomics to a broad array of biomedical research.